青风藤、青藤碱及其相关制剂的研究进展

王玺, 张智勇, 仇萍, 彭晓珊, 李正, 李元祥, 李文龙

中国药学杂志 ›› 2021, Vol. 56 ›› Issue (2) : 85-93.

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中国药学杂志 ›› 2021, Vol. 56 ›› Issue (2) : 85-93. DOI: 10.11669/cpj.2021.02.001
综述

青风藤、青藤碱及其相关制剂的研究进展

  • 王玺1, 张智勇1, 仇萍2, 彭晓珊2, 李正1, 李元祥3, 李文龙1,2*
作者信息 +

Research Progress on Caulis Sinomenii, Sinomenine and Related Preparations

  • WANG Xi1, ZHANG Zhi-yong1, QIU Ping2, PENG Xiao-shan2, LI Zheng1, LI Yuan-xiang3, LI Wen-long1,2*
Author information +
文章历史 +

摘要

青风藤作为传统中药治疗风湿痹病历史悠久,其中所含的青藤碱是祛风止痛的主要成分。现代药理研究表明,青藤碱具有良好的抗炎、镇痛、免疫抑制、戒毒等作用,对于类风湿性关节炎疗效显著。临床上已有正清风痛宁注射液、正清风痛宁片、正清风痛宁缓释片、盐酸青藤碱肠溶片等制剂,但目前治疗手段和药物剂型仍不能满足患者的需求,存在着提升空间。笔者对近年来相关的文献报道进行调研,对青风藤物质基础、药理作用、生产工艺、制剂研究等进行综述,对其联合用药、先进提取分离技术、新剂型、安全性研究进行前景展望,以期为未来新型制剂的研发和临床应用提供参考。

Abstract

Caulis Sinomenii has a long history in the treatment of rheumatoid arthritis and related diseases. Modern pharmacological research shows that sinomenine has good anti-inflammatory, analgesic, immunosuppressive, detoxification and other effects, and has a significant effect on rheumatoid arthritis. There are Zhengqing Fengtongning injection, Zhengqing Fengtongning tablets, Zhengqing Fengtongning sustained-release tablets, sinomenine hydrochloride enteric coated tablets and other preparations clinically, but the current treatment methods and drug dosage forms still can not meet the needs of patients, and there is potential for improvement. In this paper, the literature reports of sinomenine in recent years were investigated, the material basis, pharmacological action, production process and preparation research of sinomenine were collected and summarized, the prospect of its combined drug use, advanced extraction and separation technology, new dosage forms and safety research was prospected, which provide reference for the development and clinical application of new preparations in the future.

关键词

青风藤 / 青藤碱 / 类风湿性关节炎 / 正清风痛宁制剂 / 新剂型

Key words

Caulis Sinomenii / sinomenine / rheumatoid arthritis / Zhengqing Fengtongning preparation / new dosage form

引用本文

导出引用
王玺, 张智勇, 仇萍, 彭晓珊, 李正, 李元祥, 李文龙. 青风藤、青藤碱及其相关制剂的研究进展[J]. 中国药学杂志, 2021, 56(2): 85-93 https://doi.org/10.11669/cpj.2021.02.001
WANG Xi, ZHANG Zhi-yong, QIU Ping, PENG Xiao-shan, LI Zheng, LI Yuan-xiang, LI Wen-long. Research Progress on Caulis Sinomenii, Sinomenine and Related Preparations[J]. Chinese Pharmaceutical Journal, 2021, 56(2): 85-93 https://doi.org/10.11669/cpj.2021.02.001
中图分类号: R944   

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基金

国家重大新药创制项目资助(2018ZX09201011); 天津市科技计划项目资助(20ZYJDJC0090)
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